Potential neurobehavioral toxicity of sulfur in mice

Sulfur is one of the crucial elements in animal nutrition and has an influential role forming amino acids. It a common toxic element does not significantly threaten human health. The current study aimed to examine potential neurobehavioral toxicity sulfur mice by studying its effects on behavior locomotor activity. 24h median lethal dose- (LD50) mice, as determined up-and-down method was 33.22 g/kg; orally, whereas approximate dose (ALD) 36 g/kg, within 24 h. Signs poisoning were depression, gasping, Straub tail, Piloerection, tremor, dyspnea, muscle fasciculation, convulsions followed death. at 4 8 g/kg doses, after h, caused significant changes performance mice. appeared decrease motor activity open-field test (number crossed squares number rearing 3 minutes), with prolongation increase time required complete negative geotaxis reduction head pocking slight swimming scores. Repeated administration doses 1, 2, for 7 14 consecutive days also led inside pockings endurance test. Using pharmacological challenge xylazine ketamine, induced delay onset sleep shortened duration. This concludes that sulfur, despite low toxicity, toxicant.